GENETIC PRACTICES

PRE-IMPLANTATION GENETIC DIAGNOSIS (PGD)

PGD (Preimplantation Genetic Diagnosis) (Genetic Monitoring of Embryo): A blastomer (cell) of a 8-cell embryo can be taken and biopsy can be performed and chromosome structure and some gene defects of the embryo can be determined before implanting in the womb.

Recently, in parallel with the development in the gene technologies, these techniques, which were used restrictedly only in research centers, can be used more commonly and practically. Although the area develops quite rapidly, it should be applied to a limited number of patients at the clinic (risk of inherited disorder based on gender- muscle dystrophies, hemophilia etc. translocations, chromosome count disorders, some known gene defects, etc.)

 

COMPARATIVE GENOMIC HYBRIDIZATION (CGH)

Ova of the future mothers who come to the center for IVF are collected after medication. They are grown and developed by being inseminated with the male sperm with microinjection (ICSI) operation in laboratory environment. In the 3rd day of the growth, a cell is taken from embryos with 6, 7 and 8 cells by opening a hole in the membrane of the embryo by means of laser under microscope. This operation which is carried out by experienced people and advanced equipment do not harm the embryo. Rest of the embryos split up and continue their development.

 One cell taken from each embryo is examined with Microarray based Comparative Genomic Hybridization (CGH) method.